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GO:0036498: IRE1-mediated unfolded protein response (Biological process)

"The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB." [GOC:bf, GOC:PARL, PMID:22013210]


There are 279 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_10390 Sugarcane pan-transcriptome v1 33.33 % 5e-05 0.001764
Cluster_53 Sugarcane pan-transcriptome v1 0.65 % 1.2e-05 0.000102
Cluster_838 Sugarcane pan-transcriptome v1 0.33 % 0.005064 0.014073
Cluster_2096 Sugarcane pan-transcriptome v1 0.69 % 0.002394 0.032413
Cluster_4612 Sugarcane pan-transcriptome v1 1.61 % 0.001031 0.027051
Sequences (279) (download table)

InterPro Domains

GO Terms

Family Terms