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GO:0004222: metalloendopeptidase activity (Molecular function)

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


There are 14519 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_791 Sugarcane pan-transcriptome v1 1.96 % 0.004419 0.012544
Cluster_9418 Sugarcane pan-transcriptome v1 100.0 % 1e-06 1.8e-05
Cluster_6729 Sugarcane pan-transcriptome v1 33.33 % 0.002868 0.021508
Cluster_18 Sugarcane pan-transcriptome v1 2.4 % 0.000254 0.000811
Cluster_4644 Sugarcane pan-transcriptome v1 100.0 % 0.0 0.0
Cluster_873 Sugarcane pan-transcriptome v1 1.67 % 0.006056 0.024455
Cluster_295 Sugarcane pan-transcriptome v1 1.18 % 0.00199 0.019239
Cluster_11663 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.014984
Cluster_769 Sugarcane pan-transcriptome v1 1.82 % 0.000571 0.002603
Cluster_5290 Sugarcane pan-transcriptome v1 20.0 % 0.004775 0.03767
Cluster_9572 Sugarcane pan-transcriptome v1 16.67 % 0.005727 0.038946
Cluster_453 Sugarcane pan-transcriptome v1 2.2 % 3.2e-05 0.001621
Cluster_11267 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.049732
Cluster_9 Sugarcane pan-transcriptome v1 1.16 % 0.00208 0.005223
Cluster_393 Sugarcane pan-transcriptome v1 2.97 % 0.000135 0.002616
Cluster_67 Sugarcane pan-transcriptome v1 3.66 % 7.3e-05 0.001536
Cluster_3595 Sugarcane pan-transcriptome v1 33.33 % 1.4e-05 0.000533
Cluster_604 Sugarcane pan-transcriptome v1 1.54 % 0.007067 0.02023
Cluster_2059 Sugarcane pan-transcriptome v1 14.29 % 0.006679 0.027086
Cluster_1280 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.010042
Cluster_9271 Sugarcane pan-transcriptome v1 100.0 % 0.0 0.0
Cluster_5776 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.02186
Cluster_10764 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.011477
Cluster_8809 Sugarcane pan-transcriptome v1 33.33 % 0.002868 0.005797
Cluster_732 Sugarcane pan-transcriptome v1 2.63 % 0.002485 0.020694
Cluster_932 Sugarcane pan-transcriptome v1 33.33 % 0.002868 0.033936
Cluster_10645 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.030604
Cluster_562 Sugarcane pan-transcriptome v1 2.04 % 0.004088 0.018453
Cluster_1259 Sugarcane pan-transcriptome v1 66.67 % 3e-06 2.9e-05
Cluster_10319 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.014665
Cluster_12108 Sugarcane pan-transcriptome v1 33.33 % 0.002868 0.007647
Cluster_8893 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.011477
Cluster_113 Sugarcane pan-transcriptome v1 1.39 % 0.008602 0.027733
Cluster_776 Sugarcane pan-transcriptome v1 3.33 % 9.6e-05 0.00178
Cluster_342 Setaria viridis 33.33 % 0.00383 0.019533
Cluster_119 Setaria viridis 3.57 % 0.002359 0.013322
Cluster_195 Setaria viridis 2.74 % 0.00397 0.021172
Cluster_132 Setaria viridis 2.47 % 0.004863 0.037858
Cluster_23 Setaria viridis 1.71 % 0.001477 0.019794
Cluster_167 Setaria viridis 2.78 % 0.003864 0.012231
Cluster_109 Setaria viridis 3.45 % 0.000193 0.003151
Cluster_145 Setaria viridis 2.06 % 0.006897 0.031625
Cluster_205 Setaria viridis 33.33 % 0.00383 0.018724
Cluster_52 Setaria viridis 2.36 % 0.000585 0.009304
Cluster_59 Setaria viridis 2.78 % 0.003864 0.033397
Cluster_34 Brachypodium distachyon 1.56 % 0.004056 0.045039
Cluster_50 Brachypodium distachyon 2.29 % 0.00021 0.049277
Cluster_245 Oryza sativa 1.86 % 0.001303 0.011497
Cluster_285 Oryza sativa 1.9 % 0.001235 0.019407
Cluster_73 Oryza sativa 3.05 % 3e-06 0.00024
Cluster_200 Oryza sativa 2.78 % 0.004167 0.013317
Cluster_396 Oryza sativa 33.33 % 0.003977 0.045071
Cluster_734 Oryza sativa 50.0 % 0.002653 0.019234
Cluster_165 Setaria italica 2.53 % 0.005429 0.033863
Cluster_204 Sorghum bicolor 2.07 % 0.000997 0.014994
Cluster_12 Sorghum bicolor 2.54 % 7e-06 0.00385
Cluster_171 Sorghum bicolor 2.34 % 8.4e-05 0.000628
Cluster_715 Sorghum bicolor 50.0 % 0.002694 0.024245
Cluster_190 Sorghum bicolor 4.17 % 0.001927 0.008794
Cluster_8189 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.014585
Cluster_6161 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.036343
Cluster_5095 Sugarcane pan-transcriptome v1 33.33 % 0.002868 0.045885
Cluster_7814 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.036343
Cluster_4665 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.021041
Cluster_7264 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.045907
Cluster_817 Sugarcane pan-transcriptome v1 1.9 % 0.004675 0.041757
Cluster_6188 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.042081
Cluster_4795 Sugarcane pan-transcriptome v1 25.0 % 0.003822 0.030257
Cluster_5639 Sugarcane pan-transcriptome v1 33.33 % 0.002868 0.036325
Cluster_4885 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.04495
Cluster_6364 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.007651
Cluster_1590 Sugarcane pan-transcriptome v1 2.02 % 0.004169 0.015393
Cluster_4227 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.010712
Cluster_7379 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.032517
Cluster_7155 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.019765
Cluster_4165 Sugarcane pan-transcriptome v1 2.4 % 2.3e-05 0.001403
Cluster_918 Sugarcane pan-transcriptome v1 3.28 % 0.001611 0.025107
Cluster_681 Sugarcane pan-transcriptome v1 1.37 % 0.008832 0.049555
Cluster_2686 Sugarcane pan-transcriptome v1 4.05 % 5.4e-05 0.003081
Cluster_6136 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.033474
Cluster_10125 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.036343
Cluster_6713 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.021997
Cluster_3262 Sugarcane pan-transcriptome v1 2.5 % 0.002749 0.045421
Cluster_6485 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.019674
Cluster_8447 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.010042
Cluster_6803 Sugarcane pan-transcriptome v1 25.0 % 0.003822 0.025559
Cluster_4147 Sugarcane pan-transcriptome v1 3.95 % 5.8e-05 0.001413
Cluster_3030 Sugarcane pan-transcriptome v1 3.49 % 8.4e-05 0.001877
Cluster_2768 Sugarcane pan-transcriptome v1 2.99 % 0.001939 0.037935
Cluster_4416 Sugarcane pan-transcriptome v1 4.76 % 3.3e-05 0.001106
Cluster_10169 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.010259
Cluster_3082 Sugarcane pan-transcriptome v1 2.63 % 0.002485 0.018354
Cluster_3814 Sugarcane pan-transcriptome v1 2.0 % 0.004252 0.036546
Cluster_5113 Sugarcane pan-transcriptome v1 33.33 % 0.002868 0.035848
Cluster_9775 Sugarcane pan-transcriptome v1 50.0 % 0.001913 0.009245
Cluster_753 Zea mays 50.0 % 0.003188 0.044625
Cluster_242 Zea mays 2.99 % 0.005178 0.03778
Cluster_176 Zea mays 3.69 % 0.0 1e-06
Cluster_192 Zea mays 2.19 % 0.001392 0.009471
Cluster_135 Zea mays 1.42 % 0.001088 0.013321
Sequences (14519) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !