extracellular vesicles; integrative analysis; lymph node metastasis; mass spectrometry; mouth neoplasms; multi-omics; oral squamous cell carcinoma; prognosis; proteomics

A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.

Oral squamous cell carcinoma (OSCC) has high mortality rates that are largely associated with lymph node metastasis. However, the molecular mechanisms that drive OSCC metastasis are unknown. Extracellular vesicles (EVs) are membrane-bound particles …